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王学重

发布日期:2021-09-06

 

 

 

   

王学重

   

教授 博士生导师 国家特聘专家

学历(学位)

研究生(博士)

部门及职务

新材料与化工学院

    箱

0020190002@bipt.edu.cn

 

王学重,男,1963年生,博士,教授,博士生导师,国家级专家。中国石油大学化学化工学院获学士(1984)、硕士(1987)和博士学位(1990)。1990-1992任职北京化工大学自动化系讲师和副教授,1993年英国从事博士后研究,1995年受聘英国利兹大学化学工程学院讲师,之后晋升高级讲师(2001)和准教授(2005)并得到曾七次获得英国女王商业杰出成就奖的马尔文仪器公司的赞助(Malvern Reader in Intelligent Measurement and Control)。2006年获聘英国利兹大学化学工程学院过程控制和信息学讲席教授(Personal Chair in Process Control and Informatics)。2012年入选国家级专家任职华南理工大学化学化工学院。2019年就职bet356体育在线官网新材料与化工学院。

科研工作集中在制药(化学药、生物药和中药)、纳米材料、和精细化工的产品、工艺和设备开发,过程放大,模拟,工业生产的监测和智能优化控制。作为项目主持人获得英国工程和物理研究基金会、欧盟和工业界的科研项目资助超900万英镑。2012年回国后获得纵向和横向科研项目资助2000余万元。

基础和应用研究的部分成果在工业界得到了应用和技术转化。在英国期间和世界最大的制药公司辉瑞,葛兰素史克,阿斯利康,先正达等20多家企业建立了长期的密切合作关系。他帮助马尔文仪器开发的分析仪器Morphologi G被利兹大学所在的学院于2012年评选为过去六年中最具工业影响的科研成果的第一名,参与英国每六年一次的科研水平全国评比。2012年回国后和中国的制药和化工企业也建立了密切的合作(例如广药集团白云山制药、万华化学、齐鲁制药、中化国际圣奥化学、无限极(中国)、润都制药、华海药业、国邦药业、中科生物制药、东阳光药业、中科院青海盐湖所、中国工程物理研究院、天津海水淡化所、百会药业等)。

发表科研论文200余篇篇,英文专著1部 。论文被引用4300余次。获得欧洲化学工程协会的会志Chem. Eng. Res. Des. 2006-2009年论文被最多引用奖。指导毕业博士生25(英国21中国4),博士后16名,硕士生多人,其中四名博士研究生获最佳博士研究生论文奖。

 

目前的研究集中在以下几个方向:

1. 制药和结晶过程系统工程,基于晶型结构的群体粒数衡算模型模拟结晶器中晶体的生长,实现结晶过程中晶体多维形状分布的模拟以及组成的模拟;开在线三维图像获取和图像处理技术用于晶体生长过程中三维晶形结构的在线测量;基于上述突破,实现了结晶过程晶体群体形状分布的闭环自动控制。晶型筛选,智能自动化晶型筛选机器人开发。连续结晶、造粒、研磨设备的研发。

2. 制药工艺过程全流程的模拟、过程分析技术和控制技术的开发,包括合成、结晶、过滤、造粒、研磨、干燥和压片等;生物制药过程例如发酵和细胞培养等工艺的过程分析技术、控制和模拟技术的研究。

3. 在过程工业数据挖掘方面,提出了数据挖掘用于过程检测和控制,发表英文专著数据挖掘和知识发现在过程检测和控制中的应用Data Mining and Knowledge Discovery for Process Monitoring and Control – Springer LondonNew York1999)。致力于大数据挖掘和应用于制药工艺的智能化和自动化制造。

4. 在纳米生产过程的在线测量、模拟及控制、放大和高通量新产品开发这一重要领域的相关研究上,研究开发动态光散射、超声、近红外和过程层析成像仪器,和群体粒数衡算模型和计算流体力学模拟等。

5. 此外,研究工作还包括利用构效关系模型(SAR – structure activity relationship)预测纳米材料毒性。

 

主要科研项目:

  1. 广东省科技厅:药物晶体制备过程中的晶型晶习多目标优化控制, 2016.1-2018.12

  2. 国家自然科学基金重大研究计划多相反应过程中的尺度机制及调控":结晶和反应结晶过程的尺度机理研究和模拟调控,2015.1-2017.12

  3. 国家自然科学基金委重点项目:基于红外光谱和图像信息的工业结晶过程在线监测与控制优化,2017.1 -2021.12

  4. 欧盟框架7大型合作项目:SUN Project – Sustainable Nanotechnologies2014.1 - 2017.3

  5. 英国工程和物理科学研究基金委: Processing Nanoparticles in Suspension of High Solid Concentration: On-line Characterisation and Process Modelling2010.9-2014.8

  6. 英国Technology Strategy Board项目:High Value Manufacturing - Process Integration and Product Enhancement Through Crystal Growth Modifiers2009.1-2013.9

  7. 欧盟框架7大型合作项目:MARINA - Reference Methods for Managing the Risk of Engineered Nanoparticles, 2011.11-2015.5

  8. 英国工程和物理科学研究基金委: Continuous Hydrothermal Synthesis of Nanomaterials: From Laboratory to Pilot Plant, 2008.7-2011.10

  9. 企业合作项目:广药集团白云山制药、中华国际圣奥化学、万华化学集团、华海药业、国邦药业、东阳光药业、中科生物、齐鲁制药、无限极(中国)、百会制药、瑞阳制药、润都制药等, 2012.10-2018.12

 

代表性学术论著:

  1. Yi Dan Shu, Jing Jing Liu, Yang Zhang and Xue Zhong Wang*Multi-stage Multi-component Transfer Rate Morphological Population Balance Model for Crystallisation ProcessesCrystEngComm. 2019, 21(28)4212-4220.

  2. Shuai Yu, Yang Zhang, and Xue Zhong Wang, Improved Understanding of Cefixime Trihydrate Reactive Crystallization and Process Scale-up with the Aid of PAT. Organic Process Research & Development. 2019, 23(2), 177–188.

  3. Ningxin Zhan, Yang Zhang, Xue Zhong Wang, Solubility of N-tert-Butylbenzothiazole-2-sulfenamide in several pure and binary solvents. Journal of Chemical & Engineering Data. 2019, 64(3), 1051-1062.

  4. F Zhang, T Liu, W Chen, CY Ma, XZ WangSeed Recipe Design for Batch Cooling Crystallization with Application to L-Glutamic Acid. Industrial & Engineering Chemistry Research 2019 58 (8), 3175-3187

  5. 吕凤,张扬,马才云,王学重,甘露醇喷雾干燥过程中液滴粒度分布变化的群体粒数衡算模拟和实验研究,化工进展,2019, 38(2):  772-778

  6. YD Shu, Y Li, Y Zhang, L Jing J., XZ Wang, A multi-component mass transfer rate based model for simulation of non-equilibrium growth of crystals. CrystEngComm, 35(21), 5081-5282. 20 (35), 5143-5153

  7. XHT Tang, JJ Liu, Y Zhang, XZ WangStudy on the influence of lysozyme crystallization conditions on crystal properties in crystallizers of varied sizes when temperature is the manipulated variable. Journal of Crystal Growth 498, 186-196

  8. 李亚军, 王学重, 集成过程分析技术和群体粒数衡算模拟的药物材料造粒过程决策支持系统, 材料导报, 2018, 31 (10), 1721-1729

  9. 李晶晶, 周昭露, 黄生权, 鲁亮, 黄延盛, 田淑华, 李璇, 李杰, 舒逸聃, 近红外光谱技术应用于中草药口服液在线质量控制的化学计量学建模. 化工进展, 2018, 37 (5), 1923-1932

  10. YJ Li, K Wu, Y Li, Y Zhang, JJ Liu, XZ Wang, Solubility in Different Solvents, Crystal Polymorph and Morphology, and Optimization of Crystallization Process of AIBN. Journal of Chemical & Engineering Data, 2018, 63 (1), 27–38

  11. Xi H. Tang, Yang Li, Jing J. Liu, Yang Zhang,,? and Xue Z. Wang*, (2017) Process Analytical Technology (PAT) Aided Identification of Operational Spaces Leading to Tailored Crystal Size Distributions in Azithromycin Crystallization via Coordinated Cooling and Solution Mediated Phase Transition. Organic Process Research & Development, 21 (12), 1963-1971.

  12. Yan Huo,Tao Liu, Xue Z. Wang, Cai Y. Ma and Xiongwei Ni, (2017) Online Detection of Particle Agglomeration during Solution Crystallization by Microscopic Double-View Image Analysis, Industrial & Engineering Chemistry Research, 56, 11257?11269

  13. Wen J. Liu, Cai Y. Ma, Jing J. Liu, Yang Zhang*, Xue Z. Wang*, (2017) Continuous reactive crystallization of pharmaceuticals using impinging jet mixers AIChE Journal, 63: 967-974,

  14. Rui Zhang, Cai Y Ma, Jing J Liu, Yang Zhang, Yu J Liu and Xue Z. Wang*, (2017) Stereo Imaging Camera Model for 3D Shape Reconstruction of Complex Crystals and Estimation of Facet Growth Kinetics, Chemical Engineering Science, 160,171-182.

  15. Y Qin, C Zhao, X Wang and F Gao, (2017) Subspace decomposition and crtitical phase selection based cumulative quality analysis for multiphase batch processes, Chemical Engineering Science, 166: 130-143

  16. Chen Lin, Yang Zhang, Jing J Liu, Xue Z. Wang*, (2017) Study on nucleation kinetics of lysozyme crystallization, Journal of Crystal Growth, 469:59-64.

  17. Feng Lv, Jing J Liu, Yang Zhang and Xue Z Wang* (2017), Combined control of morphology and polymorph in spray drying of mannitol for dry powder inhalation, Journal of Crystal Growth, 467: 155-161.

  18. Fangkun Zhang, Tao Liu, Yan Hou, Runduo Guan, Xue Z Wang (2017)Investigation of the operating conditions to morphology evolution of beta-L-glutamic acid during seeded cooling crystallizationJournal of Crystal Growth469:136-143.

  19. Tao Liu, Yan Hou, Cai Y Ma, Xue Z Wang* (2017), Sparsity-based image monitoring of crystal size distribution during crystallization, Journal of Crystal Growth, 469: 160-167.

  20. Kui Wu, Cai Y. Ma, Jing J. Liu, Yang Zhang,* ,and Xue Z. Wang* (2016) Measurement of Crystal Face Specific Growth Kinetics, Crystal Growth & Design, 16,4855-4868.

  21. Ceyda Oksel, Vrishali Subramanian, Elena Semenzin, Cai Yun Ma, Danail Hristozov, Xue Z. Wang,* Neil Hunt, Anna Costa, Wouter Fransman, Antonio Marcomini and Terry Wilkins (2016) Evaluation of existing control measures in reducing health and safety risks of engineered nanomaterials, Environmental Science: Nano 3, 869-882.

  22. Ceyda Oksel, David A. Winkler, Cai Y. Ma, Terry Wilkins & Xue Z. Wang*(2016) Accurate and interpretable nanoSAR models from genetic programming-based decision tree construction approachesNanotoxicology, 1071001-1012.

  23. Cai Y. Ma, Jing J. Liu and Xue Z. Wang*, (2016) Measurement, Modelling and Closed-loop Control of Crystal Shape Distribution: Literature Review and Future Perspectives, Particuology, 26, 1-18.

  24. Cai Y. Ma, Jing J. Liu and Xue Z. Wang* (2016) Stereo imaging of crystal growth, AIChE Journal 62 (1), 18-25

  25. JJ Liu, CY Ma, XZ Wang*, (2016) Imaging protein crystal growth behaviour in batch cooling crystallisation. Chinese Journal of Chemical Engineering 24 (1), 101-108

  26. Yan Huo, Tao Liu, Hui Liu, Cai Y. Ma, Xue Z. Wang, (2016) In-situ crystal morphology identification using imaging analysis with application to the l-glutamic acid crystallization, Chemical Engineering Science, 148, 126-139.

  27. 周昭露,李杰,黄生权,田淑华,刘玉娇,鲁亮,张扬,黄延盛,王学重*(2016) 近红外光谱技术在中药质量控制应用中的化学计量学建模:综述和展望, 化工进展,35(6), 1627- 1645

  28. 李杰,李传坤,王春利,王学重, (2016) 基于优化动态 PLS 的常压塔重整料终馏点软测量研究, 计算机与应用化学, 33(3),06-39.

  29. Ceyda Oksel, Cai Y Ma, Jing J Liu, Terry Wilkins, Xue Z Wang* (2015) (Q) SAR modelling of nanomaterial toxicity: A critical review, Particuology 21, 1-19

  30. Wen J. Liu, Cai Y. Ma, Jing J. Liu, Yang Zhang, and Xue Z. Wang*,  (2015) Analytical technology aided optimization and scale-up of impinging jet mixer for reactive crystallization process, AIChE Journal, 61 (2), 503-517.

  31. Ceyda Oksel, Cai Y Ma, Xue Z Wang* (2015) Structure-activity relationship models for hazard assessment and risk management of engineered nanomaterials, Procedia Engineering 102, 1500-1510

  32. Rui Zhang, Cai Y Ma, Jing J Liu, Xue Z Wang*, (2015) On-line measurement of the real size and shape of crystals in stirred tank crystalliser using non-invasive stereo vision imaging Chemical Engineering Science 137, 9-21.

  33. Yang Zhang, Yanbin Jianga,?, Duanke Zhanga, Yu Qiana, Xue Z. Wang*, (2015) Metastable zone width, crystal nucleation and growth kinetics measurement in anti-solvent crystallization of -artemether in the mixture of ethanol and water. Chemical Engineering Research and Design, 9(5): 187–194.

  34. Cai Y MaJing J LiuYang ZhangXue Zhong Wang*(2015) Simulation for scale-up of a confined jet mixer for continuous hydrothermal flow synthesis of nanomaterialsThe Journal of Supercritical Fluids, 98, 211–221.

  35. C. Oksela, C.Y. Ma & X.Z. Wang*,  (2015) Current situation on the availability of nanostructure–biological activity data. SAR and QSAR in Environmental Research, 26(2), 79-94.

  36. Ratna Tantra*, Ceyda Oksel, Tomasz Puzyn, Jian Wang, Kenneth N. Robinson, Xue Z. Wang, Cai Y. Ma, Terry Wilkins, (2015) ..Nano (Q) SAR: Challenges, pitfalls and perspectives, Nanotoxicology 9 (5), 636-642

  37. Yang Zhang, Jing Jing Liu, Jian Wan, Xue Z. Wang*, (2015) Two dimensional population balance modelling of crystal growth behaviour under the influence of impurities, Advanced Powder Technology, 26 (2), 672-678

  38. R. Tantra*, C. Oksel, K.N. Robinson, A. Sikora, X.Z. Wang, T.A. Wilkins, (2015) A method for assessing nanomaterial dispersion quality based on principal component analysis of particle size distribution data. Particuology, 22, 30–38

  39. Yang Zhang, Jing J Liu, Lei Zhang, Xue Z Wang, (2015) Solubility of 2,5-Di-tert-butylhydroquinone and Process Design for Its Purification Using Crystallization, Journal of Chemical and Engineering Data, 60: 1968-1974.

  40. XZ Wang*, Y Yang, R Li, C Mcguinnes, J Adamson, IL Megson, (2014) Principal component and causal analysis of structural and acute in vitro toxicity data for nanoparticles. Nanotoxicology 8 (5), 465-476.

  41. CY Ma, M Chen, XZ Wang* (2014) Modelling and simulation of counter-current and confined jet reactors for hydrothermal synthesis of nano-materials Chemical Engineering Science 109, 26-37.

  42. WJ Liu, CY Ma, SX Feng, XZ Wang* (2014) Solubility measurement and stability study of sodium cefuroxime. Journal of Chemical & Engineering Data 59 (3), 807-816.

  43. T Liu, XZ Wang*, J Chen (2014) Robust PID based indirect-type iterative learning control for batch processes with time-varying uncertainties. Journal of Process Control 24 (12), 95-106.

  44. Y Zhang, CY Ma, JJ Liu, T Liu, XZ Wang*, (2014) Modelling and simulation of counter-current reactors for continuous hydrothermal flow synthesis of nanoparticles, Dalian Ligong Daxue Xuebao (Journal of Dalian University of Technology), 54(6):662-675.

  45. T Liu, XZ Wang*, J Chen (2014) Robust PID based indirect-type iterative learning control for batch processes with time-varying uncertainties. Journal of Process Control 24 (12), 95-106.

  46. JJ Liu, YD Hu, XZ Wang*, (2013) Optimization and control of crystal shape and size in protein crystallization process. Computers & Chemical Engineering, 57, 133-140.

  47. A Falola, A Borissova, XZ Wang*, (2013) Extended method of moment for general population balance models including size dependent growth rate, aggregation and breakage kernels, Computers & Chemical Engineering 56, 1-11.

  48. R Quesada-Cabrera, X Weng, G Hyett, RJH Clark, XZ Wang, JA Darr*, (2013) High-Throughput Continuous Hydrothermal Synthesis of Nanomaterials (Part II): Unveiling the As-Prepared Ce x Zr y Y z O2? δ Phase Diagram. ACS Combinatorial Science, 15 (9), 458-463.

  49. Ma, C.Y., X.Z. Wang*, 2012, Model identification of crystal facet growth kinetics in morphological population balance modeling of l-glutamic acid crystallization and experimental validation Chemical Engineering Science, 70(5), 22-30

  50. Boonkhao, B., Li, R.F., Wang, X.Z.*, Tweedie, R.J., Primrose, K., 2011, Making use of process tomography data for multivariate statistical process control, AIChE Journal , 57 (9) , 2360-2368

  51. Wan, J., Wang, X.Z.*, Ma, C.Y, 2009, Particle shape manipulation and optimization in cooling crystallization involving multiple crystal morphological forms, AIChE Journal, 55 (8), 2049-2061

  52. Wang, X.Z.*, Ma, C.Y., 2009, Morphological population balance model in principal component space, AIChE Journal, 55 (9), 2370-2381

  53. Ma, C.Y., Wang, X.Z.*, 2009, Inductive data mining based on genetic programming: Automatic generation of decision trees from data for process historical data analysis, Comput & Chem Eng, 33 (10), 1602-1616

  54. Wang, X.Z.*, Liu, L., Li, R.F., Tweedie, R.J., Primrose, K., Corbett, J., McNeil-Watson, F.K., 2009, Online characterisation of nanoparticle suspensions using dynamic light scattering, ultrasound spectroscopy and process tomography, Chem Eng Res & Des, 87 (6), 874-884

  55. Wang, X.Z.*, Perston, B., Yang, Y., Lin, T., Darr, J.A., 2009, Robust QSAR model development in high-throughput catalyst discovery based on genetic parameter optimization, Chem Eng Res & Des, 87 (10), 1420-1429

  56. Ma, C.Y., Wang, X.Z*., 2008, Crystal growth rate dispersion modeling using morphological population balance, AIChE Journal, 54(9),2321-2334

  57. Wang, X.Z.*, Roberts, K.J., Ma, C., 2008, Crystal growth measurement using 2D and 3D imaging and the perspectives for shape control, Chem Eng Sci, 63 (5), 1173-1184

  58. Ma, C.Y., Wang, X.Z.*, Roberts, K.J., 2008, Morphological population balance for modeling crystal growth in face directions, AIChE Journal 54 (1), 209-222

  59. Wang, X.Z.*, Calderon De Anda, J., Roberts, K.J., 2007, Real-time measurement of the growth rates of individual crystal facets using imaging and image analysis: A feasibility study on needle-shaped crystals of L-glutamic acid, Chem Eng Res & Design, 85 A, 921-927

  60. Li, R.F., Thomson, G.B., White, G., Wang, X.Z.*, Calderon De Anda, J., Roberts, K.J., 2006, Integration of crystal morphology modeling and on-line shape measurement, AIChE Journal, 52 (6),2297-2305

  61. Calderon De Anda, J., Wang, X.Z.*, Lai, X., Roberts, K.J. , 2005, Classifying organic crystals via in-process image analysis and the use of monitoring charts to follow polymorphic and morphological changes, J Process Control, 15(7), 785-797

  62. Buontempo, F.V., Wang, X.Z.*, Mwense, M., Horan, N., Young, A., Osborn, D., 2005, Genetic programming for the induction of decision trees to model ecotoxicity data, J Chem Infor & Modeling, 45 (4), 904-912

  63. De Calderon Anda, J., Wang, X.Z.*, Lai, X., Roberts, K.J., Jennings, K.H., Wilkinson, M.J., Watson, D., Roberts, D., 2005, Real-time product morphology monitoring in crystallization using imaging technique, AIChE Journal, 51 (5), 1406-1414

  64. De Calderon Anda, J., Wang, X.Z.*, Roberts, K.J.,2005,Multi-scale segmentation image analysis for the in-process monitoring of particle shape with batch crystallisers, Chem Eng Sci, 60, 1053-1065

  65. Albazzaz, H., Wang, X.Z.*, 2004, Statistical process control charts for batch operations based on independent component analysis, Ind & Eng Chem Res, 43 (21), 6731-6741

  66. Mwense, M., Wang, X.Z.*, Buontempo, F.V., Horan, N., Young, A., Osborn, D., 2004, Prediction of noninteractive mixture toxicity of organic compounds based on a fuzzy set method, J Chem Infor & Computer Sci, 44 (5),1763-1773

  67. Chen, J., Wang, X.Z.*, 2001, A new approach to near-infrared spectral data analysis using independent component analysis, J Chem Infor and Computer Sciences 41 (4), 992-1001

  68. Garci?a-Flores, R., Wang, X.Z.*, Goltz, G.E., 2000, Agent-based information flow for process industries' supply chain modeling, Computers and Chem Eng, 24 (2-7), 1135-1141

  69. Chen, B.H., Wang, X.Z.*, Yang, S.H., McGreavy, C, 1999, Application of wavelets and neural networks to diagnostic system development ,2, an integrated framework and its application, Computers and Chem Eng, 23 (7),945-954

  70. Chen, B.H., Wang, X.Z.*, Yang, S.H., McGreavy, C, 1999, Application of wavelets and neural networks to diagnostic system development,1, feature extraction, Comput  Chem Eng, 23 (7), 899-906.

  71. Wang, X.Z., 1999, Data Mining and Knowledge Discovery for Process Monitoring and Control, Springer, London, New York.

  72. 王学重,马才云,刘晶晶, 晶体三维晶面生长动力学的立体成像测定系统及方法,国家发明专利, CN103575734B 2016.06.08

  73. 王学重,马才云,刘晶晶, 一种探头式在线立体成像检测系统及方法,国家发明专利, CN103558129B, 2016.02.24

  74. 王学重,刘文菁,刘晶晶, 一种连续快速反应结晶提高晶体稳定性的装置及方法, 国家发明专利, CN103551100A, 2015.10.28

  75. 于帅,张扬,王学重,罗春,傅海燕,刘晓红,刘丹青, 一种快速定量预测药物稳定性的方法, 国家发明专利, CN107255646A, 2018.9.14